Cymbalta: Its Effectiveness And Side Effects

Many people are wary of antidepressants, which are believed to be addictive, interfere with normal thinking, and even change personality. In this article, we will talk about Cymbalta (or Duloxetine).

It belongs to the latest generation of antidepressants – dual-acting drugs that selectively block the reuptake of serotonin and norepinephrine.

The high efficacy and good tolerability of Simbalta have been proven in randomized clinical trials. The prospects of using Cymbalta in many neurological diseases, which are often associated with depression, are emphasized. The presence of a pronounced therapeutic effect in relation to pain syndromes associated with depression is of great importance.

Let’s figure out in which case a doctor can prescribe antidepressants, whether it is possible to combine them with alcohol, and what can happen with sudden weaning of Cymbalta.

What are antidepressants?

Since the 2000s, the use of these medications has increased in all worldwide countries. The funds are prescribed on the basis of the diagnosis of the attending psychiatrist, under strict control and with the ability to change the treatment regimen. Scientists have not yet come to an unambiguous conclusion about what depression appears: there are several theories, most of which mention failures in the work of neurotransmitters.

These are substances that transmit a signal between nerve and muscle cells and can have a positive effect on mood and well-being. In many cases, depression is a consequence of impaired serotonin production or the body’s ability to metabolize it. The hormone should enhance the contacts between neurons, so antidepressants do not instantly lift the mood, like, for example, delicious food, but begin to act on average after two weeks of taking.

The increase in the number of patients using antidepressants is associated not only with the rhythm of life and chronic stress but also with new generations of drugs. So, drugs of the old generation are distinguished by many side effects, while modern drugs can be drunk without harm to the body.

What are antidepressants for?

The central nervous system (CNS) is made up of a network of neurons and includes the brain and spinal cord. Antidepressants balance chemicals in the brain called neurotransmitters. Norepinephrine, serotonin, and dopamine affect the functioning of organs and systems, blood vessels, muscles, and mood. With depression, the level of neurotransmitter hormones decreases.

The response to antidepressants is individual, so doctors often have to change the treatment regimen, choosing the right substance and dosage. Depression is not necessarily an indication of the use of these drugs, and the treating physician should prescribe therapy in each case. In addition, antidepressants are rarely used without aids: psychotherapy is prescribed in parallel, the lifestyle is adjusted, and additional methods of treatment are selected.

Antidepressants without a doctor’s prescription

Depression is a diagnosis, not just temporary mood swings. The term has become so popular that people often use it to describe a state of depression and fatigue. In fact, only a doctor can diagnose true depression based on the patient’s history and taking into account all the accompanying symptoms. This is a long-term (from two weeks) decrease not only in mood, but also in cognitive abilities.

If you are not happy with the usual things, it is difficult to collect your thoughts, you feel a lack of motivation and lose the meaning of life – this is a reason to see a doctor. In no case should you choose and prescribe antidepressants yourself based on reviews and instructions.

All medications have different nuances of therapeutic effects, therefore, an incorrectly selected drug will not help at best, at worst it will greatly harm both the psyche and physical condition. You can contact a psychiatrist in confidence. Information about the treatment is a medical secret and is not disclosed.

The doctor writes a prescription based on the diagnosis, selects the dosage and appoints the time for re-admission. This is necessary to monitor the effectiveness of drugs, to make decisions about further therapy. Medicines can be bought with a prescription from a pharmacy within the time period indicated on the form. The dosage is also indicated there. When the drug is sold, the pharmacist either takes the prescription or makes a mark on it so that the patient is not given more of the drug than indicated by the doctor.

Side effects of Cymbalta

Undoubtedly, the most important indicator for any drug is its safety. More than 11,500 patients received Simbalta within the framework of the studies. The initial dose of Cymbalta is equal to the therapeutic one and is 60 mg/day (single dose). To reduce the severity of side effects in the first week of use, it is possible to take the drug at a dose of 30 mg/day. Cymbalta is prescribed for patients over 18 years of age. Currently available data indicate that there are no differences in the efficacy and tolerability of Simbalta in elderly and young patients. It is not recommended to use the drug in patients with severe renal and hepatic pathology.

In general, Cymbalta is well tolerated, the spectrum of its side effects is close to the safety profile of other modern antidepressants. Weaning off Cymbalta successfully isn’t difficult. In clinical trials, the following Cymbalta withdrawal symptoms or side effects were most often observed:

  • nausea (20%);
  • dry mouth (15%);
  • constipation (11%);
  • decreased appetite (8%);
  • increased fatigue (8%);
  • drowsiness (7%);
  • increased sweating (6%).

As a rule, it was nausea that was the reason for the discontinuation of the drug, which occurred in 1% of cases. The use of Cymbalta 30 mg during the first week reduces the likelihood of developing this side effect.

Thus, Cymbalta is a new highly effective, and fairly safe antidepressant, which will undoubtedly occupy an important place in neurological practice, possessing not only antidepressant but also analgesic activity, especially in a situation of difficult to treat neuropathic pain.

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