A 32-year-old Tennessee man was killed in a crash that happened around 2:444 am on Thursday morning, according to Florida Highway Patrol.
Troopers say a car was traveling southbound on Interstate 75 in the inside lane near Milepost 323.
Troopers say the Tennessee man was driving a pickup truck southbound on Interstate 75 in the center lane, when a car entered the center lane and collided with a trailer towed by the pickup truck.
The impact caused the pickup truck to rotate and collide with a guardrail, eventually traveling over the
guardrail and overturning before coming to final rest.
Investigators say the 32-year-old man suffered fatal injuries at the scene of the crash.
Three passengers in the pickup truck, all from Spring Hill, Tennesee, suffered serious injuries in the crash, including a 12-year-old boy, a 31-year-old woman, and a 32-year-old man.
The driver of the car, 40-year-old John Andrew Henderson, Kissimmee, was arrested by FHP Troopers for DUI Manslaughter, DUI Serious Injury, and DUI Property Damage.
Henderson was later booked into the Sumter County Jail.